Fundstücke
11-2025
Wissens- und Nachdenkenswertes:
Neuigkeiten, Meinungen, Erfahrungsberichte,
(Psychiatrie-)Kritik, Verbesserungsvorschläge und mehr …
.
| CVI/Zerebral bedingte Sehbeeinträchtigungen |
| CVI Scotland hat die Homepage neu gestaltet: Und hat inzwischen auch eine unglaubliche ‚Reichweite‘: Our Global Reach The information about CVI on our website is relevant throughout the world. https://cviscotland.org/global_reach.php ♥ |
| CVI Scotland – Blogs & News Yellowstone Blog 41 Cell Phone Ban & Accessibility with CVI https://cviscotland.org/news/yellowstone-blog-41-cell-phone-ban-and-accessibility-with-cvi CVI Scotland: “…With CVI and other hidden disabilities, this may be a factor that needs more thought. …Perhaps the real challenge isn’t whether phones belong in schools, but how we can ensure that the few who genuinely need them are supported, understood, and included.” [Übersetzt in etwa: …Bei zerebral bedingten Sehbeeinträchtigungen und auch bei anderen nicht sichtbaren Behinderungen könnte dies ein Faktor sein, der noch mehr berücksichtigt werden muss. …Vielleicht liegt die eigentliche Heraus-forderung nicht darin, zu entscheiden, ob Handys in Schulen gehören oder nicht, sondern darin, wie wir sicherstellen können, dass die wenigen, die ihr Handy wirklich brauchen, unterstützt, verstanden und einbezogen werden. …] |
| CVI Scotland – Blogs & News AI Videos https://cviscotland.org/news/ai-videos VIDEO-SAMMLUNG ZUM THEMA ‘ZEREBRAL BEDINGTE SEHBEEINTRÄCHTIGUNG‘, ERSTELLT VON KÜNSTLICHER INTELLIGENZ, MIT ERLÄUTERUNGEN: “A growing collection of short AI-created videos about cerebral visual impairment, presented with captions explaining each topic.” ↓ What is visual recognition and how does cerebral visual impairment affect it? CVI: A Disabling Visual Impairment (Even When You Can See Small Things) What Is Perception & How Does CVI Affect It? Bright Lights, Light Gazing & CVI When Expressions Aren’t Seen* - [DIE THEMEN: Was ist visuelles Erkennen und wie wirkt sich eine zerebrale Sehbeeinträchtigung darauf aus? CVI: Eine behinderende Sehbeeinträchtigung (auch wenn man kleine Dinge sehen kann) Was ist Wahrnehmung und wie wirkt sich CVI darauf aus? Helles Licht, ins-Licht-starren & CVI Wenn Gesichtsausdrücke nicht gesehen/erkannt werden*] -- [[ * ‚Dreifaches‘ Problem: 1. Sowohl meine Mimik ist, wie man mir schon gesagt hat, kaum wahrnehmbar, und 2. das bisschen Mimik, das vielleicht tatsächlich doch wahrnehmbar ist, wird of auch noch falsch interpretiert, und 3. für mich die Gesichtsausdrücke meiner Mitmenschen auch oft (nicht immer, aber oft) nur schwerlich ‚decodierbar‘ sind, kommt es zwangsläufig zu Fehlinterpretationen und Missverständnissen, auf beiden Seiten. – Siehe dazu auch: Eintrag 10.11.2025; Blogbuchgedanken – CVI; Diskussionsseite – Zuschreibungen Zum Nachdenken – Theory of Mind ]] |
| Und siehe auch: Eintrag 01.11.2025 – 1. Eintrag 04.11.2025 – 2., 3. Eintrag 11.11.2025 |
|
|
| Autismus, Schizophrenie, Psychiatrie … |
| 01.11.2025 – 1. Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults Kim GS, Chandio BQ, Benavidez SM, et al. Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults. Cerebral Cortex (New York, N.Y. : 1991). 2025 Nov;35(11):bhaf291. DOI: 10.1093/cercor/bhaf291. PMID: 41231222; PMCID: PMC12613831. https://europepmc.org/article/MED/41231222 “Abstract: …Our findings rigorously demonstrate that white matter microstructure alterations in autism may be greater within specific regions of individual tracts, and that the implicated tracts are distributed across the brain.” -- Infos bei Wikipedia – ZUSAMMENHÄNGE – zum Nachdenken: Posterior thalamic radiation https://en.wikipedia.org/wiki/Optic_radiation “…the optic radiation (also known as the geniculocalcarine tract, the geniculostriate pathway, and posterior thalamic radiation) are axons from the neurons in the lateral geniculate nucleus to the primary visual cortex. The optic radiation receives blood through deep branches of the middle cerebral artery and posterior cerebral artery.” [Function: The optic radiation contains feedforward tracts that transmit visual information (from the retina of the eye) from the geniculate nucleus to the visual cortex, and also feedback tracts from the visual cortex to the neurons in the LGN that project to them. The function of the feedback from the visual cortex back to the LGN is unknown. The optic radiation is activated during working memory tasks. The optic radiations are usually unilateral and commonly vascular in origin. Field defects, therefore, develop abruptly, in contrast to the slow progression of defects associated with tumors.] - Inferior longitudinal fasciculus (ILF) https://en.wikipedia.org/wiki/Inferior_longitudinal_fasciculus [Functions: Summarising studies from healthy individuals, intraoperative and lesional findings, this white matter bundle supports functions linked to the ventral visual stream* such as object recognition and face perception, Likewise, disorders linked to this white matter tract are disorders with perturbed visual perception such as associative visual agnosia, prosopagnosia, visual amnesia, visual hypo-emotionality; but also some forms of autism spectrum disorders, schizophrenia and alexia. …] Siehe dazu: Zum Nachdenken – Kontrastwahrnehmung - Superior longitudinal fasciculus (SLF) https://en.wikipedia.org/wiki/Superior_longitudinal_fasciculus (SLF) Siehe dazu: Blogbuchgedanken – Propriozeption (ÜBERSICHT: SLF I, II und III) - Uncinate fasciculus https://en.wikipedia.org/wiki/Uncinate_fasciculus „… Its function is unknown though it is affected in several psychiatric conditions. It is one of the last white matter tracts to mature in the human brain. …” [Development; Clinical significance] -- Siehe dazu auch den nachfolgenden Eintrag und: Aktuelles – 1. Neue ‚Konzepte‘ wären hilfreich … Blogbuchgedanken – Frühgeborene, Schizophrenie, ‚Spaltungsirresein‘ Diskussionsseite – Migrälepsie (-> Unzinatusanfälle) Limbisches System Wunderwerk Gehirn – Kommissurenbahnen, Rindenarchitektonik, Substantia alba Wunderwerk Gehirn – Hinsinus (-> Arterielle Versorgung, Venöser Abfluss) Leitungsbahnen Zum Nachdenken – Projektionsbahnen |
| 01.11.2025 – 2. The Development of Lateralized Brain Oscillations in Infants: Lessons From Autism Blanco-Gomez G, O'Reilly C, Webb SJ, Elsabbagh M, BASIS Team. The Development of Lateralized Brain Oscillations in Infants: Lessons From Autism. Developmental Psychobiology. 2025 Nov;67(6):e70101. DOI: 10.1002/dev.70101. PMID: 41194536; PMCID: PMC12589938. https://europepmc.org/article/MED/41194536 “Abstract: The lateralization of brain activity is important for language processing and attention, and atypical patterns of lateralization have been linked to many neurodevelopmental disorders, including autism spectrum disorder (ASD). … Overall, examining the developmental trajectories of lateralization is a crucial step toward creating more accurate models of brain development and better understanding the underlying mechanisms of neurodevelopmental disorders.” - Aus dem Fulltext, zum Nachdenken: „…There is evidence of synaptic dysfunction in ASD, which results in aggressive over‐pruning of axons. These synaptopathies can lead to over‐activation of one hemisphere and differing lateralization patterns, leading to a wide array of symptoms. …” -- Infos bei Wikipedia: Lateralisation des Gehirns https://de.wikipedia.org/wiki/Lateralisation_des_Gehirns “…Einige Funktionen oder Teilfunktionen des Gehirns werden bevorzugt in einer der beiden Gehirnhälften ausgeführt. Die Aufteilung von Prozessen auf die rechte und linke Hälfte wird als Lateralisation bezeichnet. … Das Großhirn besteht aus zwei stark gefurchten Halbkugeln (Hemisphären), die durch einen tiefen Einschnitt – die Hirnlängsfurche (Fissura longitudinalis) – voneinander getrennt sind. Die Verbindung zwischen den beiden Hemisphären wird durch einen dicken Nervenstrang, den so genannten Balken (Corpus callosum), hergestellt. …“ - Lateralization of brain function https://en.wikipedia.org/wiki/Lateralization_of_brain_function „…The median longitudinal fissure separates the human brain into two distinct cerebral hemispheres connected by the corpus callosum. Both hemispheres exhibit brain asymmetries in both structure and neuronal network composition associated with specialized function. Lateralization of brain structures has been studied using both healthy and split-brain patients.“ [Clinical significance] ↓ https://de.wikipedia.org/wiki/Geschwind-Behan-Galaburda-Modell https://en.wikipedia.org/wiki/Geschwind%E2%80%93Galaburda_hypothesis - Synaptopathy https://en.wikipedia.org/wiki/Synaptopathy „…Some diseases of unknown etiology have been proposed to be synaptopathies. Examples include autism spectrum disorder and schizophrenia. Synaptic dysfunction can also occur in neurodegenerative disorders such as Alzheimer's.” ↓ Einzelnachweis/Ref. 5: Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits PMID: 28986278 - DOI: 10.1016/j.pnpbp.2017.09.026 – No abstract “…One of the most reproducible findings in ASDs is that autistic brains have alterations in brain connectivity. … There is some evidence for gross differences in white matter volume in certain brain regions in ASDs, that may or may not lessen with age. … Microstructural white matter abnormalities—as defined by differences in fractional anisotropy of diffusion tensor imaging (DTI) studies—are a commonly reported finding in ASDs. …” - Einzelnachweis/Ref. 6: Synapse pathology and translational applications for schizophrenia PMID: 27633835 - DOI: 10.1016/j.neures.2016.09.001 – Free article “…these results indicate that excessive complement activity could account for the reduced numbers of synapses in the brains of individuals with schizophrenia. … 4. Conclusion: This review has discussed the involvement of glutamatergic disturbances in the pathophysiology of schizophrenia.” -- Siehe dazu auch obigen Eintrag und: Aktuelles – 1. Neue ‚Konzepte‘ wären hilfreich … Aktuelles – Autismus-Theorie (Auf der Suche nach einer Autismus-Theorie) Blogbuchgedanken – Linkshändigkeit, Planum temporale Diskussionsseite – Epileptoide Krankheiten, Migrälepsie Lernprobleme, …zum Weiterlesen Wunderwerk Gehirn – Kommissurenbahnen (und Corpus callosum) Zum Nachdenken – Händigkeit |
| 01.11.2025 – 3. A study on the relationship between psychological resilience, vagal tone, and social adaptation: A non-pharmacological treatment perspective based on left-behind children Liu X, Zhang L, Zhang M, Li N. A study on the relationship between psychological resilience, vagal tone, and social adaptation: A non-pharmacological treatment perspective based on left-behind children. Medicine. 2025 Nov;104(45):e45235. DOI: 10.1097/md.0000000000045235. PMID: 41204572; PMCID: PMC12599727. https://europepmc.org/article/MED/41204572 “Abstract: …Psychological resilience is significantly associated with better social adaptation among left-behind children, and this relationship may be partially explained by vagal tone (HRV), which plays a potential mediating role. This study provides physiological support for HRV-based non-pharmacological psychological interventions and holds significant theoretical and practical value.” -- Siehe dazu auch den nachfolgenden Eintrag und: Fundstücke-02-2023, Eintrag 03.02.2023 |
| 01.11.2025 – 4. Gut sensing of food ingredients and interoception-mediated regulation of feeding and glucose metabolism Physiological Reports, 01 Nov 2025, 13(21):e70636 https://doi.org/10.14814/phy2.70636 PMID: 41146469 PMCID: PMC12559028 https://europepmc.org/article/MED/41146469 „…In this context, the ability of the brain to anticipate and respond to food‐related information through vagal sensory pathways before nutrients are absorbed into the systemic circulation may represent an essential mechanism for maintaining homeostasis. Moreover, understanding this vagal pathway holds potential for developing novel therapeutic strategies for metabolic disorders such as obesity and diabetes, as well as for improving mental health conditions including depression.” -- Siehe dazu auch: Glossar – Plexus (Sympathikus, Parasympathikus, Enterisches Darmwandnervensystem) Bei Wikipedia: |
| 03.11.2025 High Consumption of Ultra-Processed Foods Is Associated with Genome-Wide DNA Methylation Differences in Women: A Pilot Study Rodrigues AE, Fernandes AE, Carrasco AGM, et al. High Consumption of Ultra-Processed Foods Is Associated with Genome-Wide DNA Methylation Differences in Women: A Pilot Study. Nutrients. 2025 Nov;17(21):3465. DOI: 10.3390/nu17213465. PMID: 41228537; PMCID: PMC12609220. https://europepmc.org/article/MED/41228537 “Conclusions: High UPF consumption was associated with altered DNA methylation patterns, suggesting a potential epigenetic mechanism underlying the negative health effects of UPFs. This pilot study provides a model for future research with larger samples.” -- Infos bei Wikipedia: https://de.wikipedia.org/wiki/NOVA_(Lebensmittelklassifikation)#Hochverarbeitete_Lebensmittel https://en.wikipedia.org/wiki/Ultra-processed_food [Health effects; How to identify ultra-processed foods; Environmental impact] -- Dazu bitte auch lesen: A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression Islam N, Semmler A, Starling J, Voisey J. A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression. Nutrients. 2025 Nov;17(21):3479. DOI: 10.3390/nu17213479. PMID: 41228551; PMCID: PMC12610701. https://europepmc.org/article/MED/41228551 “…It is possible that micronutrient imbalances could contribute to the development of perinatal depression through their roles in neurotransmitter synthesis and neuroendocrine and neuroimmune pathways. Micronutrient imbalances are more likely during the perinatal period due to the additional physiological demands on the body during this time. … Conclusion: This review found that vitamin D deficiency has the greatest evidence of an association with perinatal depression. The evidence for other micronutrients is mixed, inconclusive, or limited. Further research is required to determine the significance of these micronutrients in the development of perinatal depression.” -- Siehe dazu auch: Essen & Co. – Wasser- und fettlösliche Vitamine Mineralstoffe, Spurenelemente |
| 03.11.2025 Complementary therapies for the management of attention deficit hyperactivity disorder in children: a scoping review Revista Latino-americana de Enfermagem, 03 Nov 2025, 33:e4701 https://doi.org/10.1590/1518-8345.7915.4701 PMID: 41191698 PMCID: PMC12587758 https://europepmc.org/article/MED/41191698 Aus dem Fulltext: “…First-line pharmacological treatment for ADHD includes the use of stimulants such as amphetamine (AMP) and methylphenidate (MPH), both of which have been shown to have comparable efficacy. However, children treated with stimulants often experience negative side effects such as sleep disturbances, decreased appetite, headaches, irritability, and stomach pain. … Conclusion: The use of complementary therapies presents promising potential for improving symptoms of pediatric ADHD, with particular emphasis on mind-body therapies such as neurofeedback; in supplementation, the use of polyunsaturated fatty acids, zinc, and iron; in herbal therapy, the use of Ginkgo biloba; and in dietary therapy, the oligo-antigenic diet. …” -- Buchempfehlung – zur Erinnerung … Julia Rucklidge, Bonnie Kaplan „The Better Brain – How Nutrition Will Help You Overcome Anxiety, Depression, ADHD and Stress“; vermilion ‚Introduction: Finding Answers in Nutrition, Not in Pharmacy: There is an enormous crisis in many Western countries around the world right now. Not just an economic crisis or an obesity crisis or an opioid crisis. A mental health crisis. …‘ (S. 1) |
| 04.11.2025 – 1. Dietary Patterns, Not Gut Microbiome Composition, Are Associated with Behavioral Challenges in Children with Autism: An Observational Study Di Benedetto G, Sorge G, Sarchiapone M, Di Martino L. Dietary Patterns, Not Gut Microbiome Composition, Are Associated with Behavioral Challenges in Children with Autism: An Observational Study. Nutrients. 2025 Nov;17(21):3476. DOI: 10.3390/nu17213476. PMID: 41228547; PMCID: PMC12610858. https://europepmc.org/article/MED/41228547 “…By contrast, dietary patterns strongly differentiated ASD from non-ASD participants: children with ASD consumed higher levels of sweets and sugary foods, lower portions of vegetables, and exhibited reduced overall dietary diversity. Statistical analyses confirmed that dietary factors, rather than microbial composition, explained variation in ASD diagnosis. …” -- Siehe dazu auch: Einträge 03.11.2025 |
| 04.11.2025 – 2. Perceptual interpretation of biological motion relates to autistic traits in children born very preterm Johansson M, Kochukhova O, Larsson E, Montgomery C, Kaul YF. Perceptual interpretation of biological motion relates to autistic traits in children born very preterm. Experimental Brain Research. 2025 Nov;243(12):242. DOI: 10.1007/s00221-025-07186-6. PMID: 41186723; PMCID: PMC12586206. https://europepmc.org/article/MED/41186723 “Abstract: Children born very preterm (VPT, ≥ 28 to < 32 gestational weeks) and extremely preterm (EPT, < 28 weeks) are at higher risk for autistic traits and biological motion (BM) processing deficits. …” -- Siehe dazu auch: Fundstücke-09-2025, Eintrag CVI Scotland – Blogs & News: Newsletter 55 Why do so many children with visual impairment have features of autism? https://cviscotland.org/news/newsletter-55-why-do-so-many-children-with-visual--05-09-2025 |
| 04.11.2025 – 3. Sleep Disturbances and Disorders in Children and Adolescents with Cerebral Palsy: A Narrative Review Rausch RA, Miller C, Hensler A, Goetting MG, Patel DR. Sleep Disturbances and Disorders in Children and Adolescents with Cerebral Palsy: A Narrative Review. Journal of Clinical Medicine. 2025 Nov;14(21):7828. DOI: 10.3390/jcm14217828. PMID: 41227224; PMCID: PMC12609432. https://europepmc.org/article/MED/41227224 “Background/Objectives: Children and adolescents with cerebral palsy experience multiple associated comorbidities or impairments that impact their day-to-day life and psychosocial functioning. Sleep difficulties, disturbances, or disorders are a widely recognized concern for youth with cerebral palsy. …” -- Siehe dazu auch: Aktuelles – CP/Cerebral palsy/Zerebralparese Fundstücke-04-2024, Einträge zu Cerebral palsy, und Eintrag 10.04.2024 Fundstücke-07-2025, Eintrag CVI Scotland Blogs & News: https://cviscotland.org/news/cerebral-palsy-and-cvi-paper-08-04-2024 |
| 04.11.2025 – 5. “The Stuff of Demonic Nightmares”: People Describe Withdrawal from Psychiatric Drugs https://www.madinamerica.com/2025/11/the-stuff-of-demonic-nightmares-people-describe-withdrawal-from-psychiatric-drugs/ [Login article] „A new article published in Health Expectations finds that people withdrawing from psychiatric drugs often experience difficult withdrawal symptoms, a lack of support, trouble finding tapering resources, anger, frustration, loneliness, and hopelessness. … Several respondents found that online peer support forums facilitated the withdrawal process by providing information, resources and support. … These findings may encourage a broader discussion about the role of these medications in treating mental illness and when to start or stop treatment.” ↓ Open Access: ‘I Wish It Were More Often Told to People Before They Are Prescribed These Medications How Hard It Is to Get Off Them’: A Qualitative Descriptive Analysis of Free-Text Responses to a Survey on Reducing and Stopping Psychiatric Medication Miriam Boland, Agnes Higgins, Sookyung Kwak, Cathal Cadogan First published: 11 August 2025 https://doi.org/10.1111/hex.70384 https://onlinelibrary.wiley.com/doi/10.1111/hex.70384 “…Rising prescription trends have led to concerns over the extent of the clinical improvement they provide in managing mental illnesses, as well as their potential for adverse effects and withdrawal symptoms. … Many respondents reported that the tapering process took years to complete. … Several respondents reported feelings of loneliness and hopelessness while undertaking the withdrawal process. Some respondents feared that they had been permanently changed by taking psychiatric medication and that they would be on them for life. … Adverse effects were the main reason that respondents from the lived experience group reduced/stopped their psychiatric medication. …” -- Siehe dazu auch: Eintrag 21.11.2025 und 19.11.2025 – 1. -- [[ Arbeiten, in denen die Ausagen der Befraten/Untersuchten als Zitate aufgeführt sind, finde ich enorm hilfreich – wie hier in dieser obigen Arbeit. Beispielzitate daraus: ]] · I took an SSRI for 6 months, became increasingly depressed and suicidal, then tapered off. · The myth that people relapse if they are not on medication still informs the practice of most psychiatrists in my experience and they still believe the chemical imbalance hypothesis. · The hell endured in protracted withdrawal is the stuff of demonic nightmares. · Getting off the antipsychotic I was on has freed me from toxic psychiatry, brought more feeling, authentic emotion, more life, and more appreciation of life. · Withdrawal is the worst, indescribable, socially isolating experience. · I had to do this all on my own, I lost everyone and everything important. · Why are the pharmaceutical companies not accountable for the damage they have caused to so many. ↓ Dazu bitte auch lesen: Why Lawsuits About Psychiatric Malpractice Are Difficult to Win “…The efficacy of antipsychotics is poor, and the risk of serious harms is so great that forced medication seems to do far more harm than good. …” Siehe dazu auch: Eintrag 21.11.2025 (Und zum Nachdenken) Und siehe auch: Eintrag 13.11.2025 |
| 04.11.2025 – 6. When the Family Is the Patient https://www.madinamerica.com/2025/11/when-the-family-is-the-patient/ The family operating system / Family therapy: “…The language in this meeting is different than that of a biologically oriented psychiatrist. Questions about relationships and family stories, rather than symptoms, set the stage for the family to begin to think differently about their child. The mood of the session is supportive, looking for family strengths, as well as being mildly disruptive in the way it challenges the idea that the child is the problem. …” [Übersetzt in etwa: …Die Sprache bei diesen Treffen unterscheidet sich von der eines biologisch orientierten Psychiaters. Es sind Fragen zu Beziehungen und zu Familiengeschichten statt zu Symptomen, die es der Familie ermöglichen, anders über ihr Kind zu denken. Die Stimmung während der Sitzung ist unterstützend, sucht nach familiären Stärken und ist zudem leicht ‚störend‘, indem sie die Vorstellung herausfordert, dass das Kind das Problem ist. …] -- Dr. Salvador Minuchin – Infos bei Wikipedia: https://de.wikipedia.org/wiki/Salvador_Minuchin https://en.wikipedia.org/wiki/Salvador_Minuchin - |
| 06.11.2025 Association between prenatal exposure to antihypertensive medication and neurodevelopmental and educational outcomes in children Alkhalaf S, Singh S, Pell JP, et al. Association between prenatal exposure to antihypertensive medication and neurodevelopmental and educational outcomes in children. Scientific Reports. 2025 Nov;15(1):38929. DOI: 10.1038/s41598-025-22887-2. PMID: 41198838; PMCID: PMC12592423. https://europepmc.org/article/MED/41198838 “Discussion: In this large, unselected population cohort, ASD was associated with prenatal exposure to anti-hypertensive medication; specifically, beta-blockers. The association was independent of lifestyle, maternal and pregnancy confounders and appeared to be partially mediated by birth outcomes including birthweight, gestational age at delivery and Apgar score. … The most common antihypertensive medications used during pregnancy are methyldopa, labetalol, and nifedipine with different safety profiles. … Importantly, ASD was not associated with untreated HDP, suggesting a potential medication-specific effect rather than an effect of the underlying condition. … Therefore, our findings that both treated HDP and untreated HDP were associated with learning and communication difficulties contribute to the limited existing evidence. … We found no evidence that either HDP or anti-hypertensive medication were associated with ADHD in offspring. …” |
| 10.11.2025 A sensorimotor basis for facial expressivity differences in autism Bress KS, Quinde-Zilbut J, Zoltowski AR, et al. A sensorimotor basis for facial expressivity differences in autism. Imaging Neuroscience (Cambridge, Mass.). 2025 ;3:IMAG.a.981. DOI: 10.1162/imag.a.981. PMID: 41230421; PMCID: PMC12603653. https://europepmc.org/article/MED/41230421 „Abstract: …Critically, we demonstrate that upper face actions are selectively diminished in autism, and that the relationship between sensorimotor connectivity and facial behavior diverges between autistic and nonautistic individuals. These findings offer the first direct evidence of a sensorimotor basis for altered facial expressivity in autism, challenging long-held assumptions about the underlying mechanisms of this communication barrier and pointing toward new targets for therapeutic intervention.” -- Aus dem Fulltext: “…Compared with facial expression perception, little work has been published addressing the etiology of atypical facial expression production in autism. This bias has created a significant knowledge gap regarding how autistic individuals’ emotions are understood by others and reinforces unsubstantiated assumptions about the relationship between emotional expression and the experience of emotions in autism. Moreover, it has led to an absence of evidence-based, autism-centered interventions targeting this critical communication barrier. The production of facial expressions is a sophisticated sensorimotor behavior that involves precise contraction of the facial muscles guided by dynamic sensory feedback. Given that (i) facial expressions are a sensorimotor behavior, (ii) sensorimotor deficits are a core characteristic of autism (American Psychiatric Association, 2013), and (iii) other facial sensorimotor functions such as feeding and speech are disrupted in autism, sensorimotor differences may contribute significantly to atypical facial expression behavior and represent a potential therapeutic target. …” -- Siehe dazu auch: Zum Nachdenken – Mimik, FACS, Fasciculus retroflexus |
| 11.11.2025 Argo Delphi consensus statement on red flags and clinical gateways towards rare disease diagnosis Limongelli G, De Iaco F, Mosca M, et al. Argo Delphi consensus statement on red flags and clinical gateways towards rare disease diagnosis. Scientific Reports. 2025 Nov;15(1):39411. DOI: 10.1038/s41598-025-23081-0. PMID: 41219277; PMCID: PMC12606334. https://europepmc.org/article/MED/41219277 Aus Table 2: “25: Involvement of the school system and teachers Promote awareness among preschool, elementary, and secondary school teachers and educators about the signs of potential health issues (e.g. unusually high number of absences for different specialist visits) and how to recognize them. Autism spectrum disorders and specific learning disorders, such as dyslexia, dysgraphia, dysorthography, and dyscalculia, should be considered for further investigations. Offer guidance on how educators can assist parents in seeking appropriate clinical assessments for their children.” -- Siehe dazu auch: Fundstücke-02-2023, Eintrag 10.02.2023 – 1. (ESSENCE-Konzept) Buchtipp – zur Erinnerung: Gillberg C. - The Essence of Autism and Other Neurodevelopmental Conditions. Rethinking co-Morbidities, Assessment, and Intervention. London and Philadelphia: Jessica Kingsley Publishers (2021) |
| 13.11.2025 Psychiatrists Do Not Apologize https://www.madinamerica.com/2025/11/psychiatrists-do-not-apologize/ “…In other words, psychiatrists destroyed our lives. … The failure to apologize brings untold pain to us victims. … For four years, from the age of sixteen until the age of twenty, I was tortured by American psychiatrists who suffered under the delusion that homosexuality was a mental illness. … Saying that homosexuality was a mental illness was not the only mistake that psychiatrists made and that affected my life in tragic ways. The other mistake was their assumption that schizophrenia is incurable. … My story is obviously a scandal, for it raises a very important question: since psychiatrists were wrong in saying that homosexuality is a mental illness and that schizophrenia is incurable, then is it possible that they are wrong about everything else? … Psychiatrists want their patients to think that they know more about their patient’s life than the patient does. However, the psychiatrist only knows what the patient tells him, and what the patient tells the psychiatrist about himself is only a very small fraction of what the patient really knows about himself. I remember sitting in front of so many psychiatrists who had nothing to say because they knew nothing about me. They knew nothing because I realized quite rightly that they were not intellectually equipped* to begin to understand the complications of my life, the problems of my mind and the mysteries of my soul. … I believe that the only true cure for mental illness is love. … Psychiatric abuse is a gigantic taboo. We victims should make our voices be heard.” ♥ -- Siehe dazu auch: Eintrag 19.11.2025 Ausserdem – Psychiatrie Blogbuchgedanken – Insulinschocktherapie, Schizophrenie, ‘Spaltungsirresein’ -- [[ * …they were not intellectually equipped … - Das musste ich leider auch schon denken, ja. Traurig, oder? Intelligenz sei die Summe aus Fantasie, also Vorstellungskraft, und Einfühlungs-vermögen, las ich einmal in einem Buch – und Neugier gehört vermutlich auch dazu. Denn wie sagte zum Beispiel auch Albert Einstein: „Phantasie/Vorstellungskraft ist wichtiger als Wissen, denn Wissen ist begrenzt.“ „Ich habe keine besondere Begabung, sondern bin nur leidenschaftlich neugierig." Siehe: https://de.wikiquote.org/wiki/Albert_Einstein ]] -- Dazu bitte auch lesen: Phenomenological Therapy: Centering Subjectivity https://www.madinamerica.com/2025/11/phenomenological-therapy-centering-subjectivity/ “…Perhaps the most profound benefit is liberating clients from a system that labels normal and abnormal, inviting them to restore self-trust and learn what authentic being and action is for them. …” ↓ Edmund Husserl – Infos bei Wikipedia: https://de.wikipedia.org/wiki/Edmund_Husserl „…In seinem Spätwerk kritisierte Husserl, dass die modernen Wissenschaften mit ihrem Anspruch, die Welt objektivistisch zu erfassen, die Fragen der Menschen nach dem Sinn des Lebens* nicht mehr beantworten. …“ In der englischen Wikipedia: https://en.wikipedia.org/wiki/Edmund_Husserl * Siehe dazu auch: Eintrag 28.11.2025 – 2. -- A Call for Ecological Medicine: Rethinking Mental Health as a Web of Connections https://www.madinamerica.com/2025/11/can-medicine-learn-to-treat-ecosystems-not-just-patients/ “A new consensus statement argues that medicine should treat mental and physical health as products of relationships with people, animals, and the living world. …” -- Und bei Wikipedia, zum Nachdenken: https://de.wikipedia.org/wiki/Psychopharmakologie „Probleme der Psychopharmakologie sind das hohe Ansprechen auf Placebos bei psychischen Störungen, das unterschiedliche Ansprechen der Substanzen bei einzelnen Menschen, die relativ geringe Wirksamkeit und die fehlenden Kenntnisse über die Ursachen der psychischen Störungen.“ In der englischen Wikipedia: https://en.wikipedia.org/wiki/Psychopharmacology - https://en.wikipedia.org/wiki/Neuropsychopharmacology “Neuropsychopharmacology supersedes psychopharmacology in the areas of ‘how’ and ‘why’, and additionally addresses other issues of brain function. … Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.” -- Siehe dazu auch den nachfolgenden Eintrag und: Eintrag 15.11.2025, 18.11./20.11.2025 und 19.11.2025 – 2. Aktuellles – ESS/Hypopituitarismus, Estrogen/Cholesterin/Cortisol, Imbalances Blogbuchgedanken – Aminosäuresequenzen, Dopamin-‚Update‘ Zum Nachdenken – Hypopituitarismus Gedankensplitter – ‚Layer to layer‘, Neuroleptika, UAWs Etc. |
| 15.11.2025 New Evidence in Support of Tapering Protocols for First-Episode Psychosis “…Treatment guidelines generally support trying to discontinue antipsychotics in patients diagnosed with ‘first-episode psychosis’ after one or two years of initial use, but these guidelines also advocate preventing relapses*. Consequently, the guidelines often lead to first-episode patients being maintained on antipsychotics indefinitely, as discontinuation is associated with an increased risk of relapse. …” [Übersetzt in etwa: …Behandlungsrichtlinien unterstützen zwar allgemein den Versuch, Antipsychotika bei Patienten mit einer 'First-Episode-Psychosis' nach ein bis zwei Jahren der Erstanwendung abzusetzen, empfehlen aber auch, Rückfälle zu verhindern. Folglich führen diese Richtlinien oft dazu, dass diese Patienten eben doch unbegrenzt Antipsychotika erhalten, da ein Absetzen mit einem erhöhten Rückfallrisiko* einhergeht. …] [[ * Nach meiner Erfahrung ist es aber in erster Linie nicht das nicht mehr verabreichte Medikament, das zu einem Rückfall führen kann, sondern vielmehr die Diagnose, die zu einem (negativ) veränderten Selbstbild und vor allem auch zu einem (negativ) veränderten Bild führen, wie man von anderen wahrgenommen wird . – Siehe dazu auch: Eintrag 13.11.2025; Diskussionsseite – Zuschreibungen (und wenn diese beschädigen …) Und bei Wikipedia: Stigmatisierung psychisch Kranker https://de.wikipedia.org/wiki/Stigmatisierung_psychisch_Kranker „…Neben unterstellter Inkompetenz gehören Gefährlichkeit und Selbstverant-wortlichkeit zu den häufigsten Vorurteilen über Menschen mit psychischen Erkrankungen. Medienberichte, die den Zusammenhang zwischen psychischen Störungen und Gewalt übertreiben, festigen das Stereotyp der Gefährlichkeit und führen zu einer öffentlichen Angst vor psychisch Kranken. …“ Mental disorder – Stigma https://en.wikipedia.org/wiki/Mental_disorder#Stigma „…For millennia, society did not treat persons suffering from depression, autism, schizophrenia and other mental illnesses much better than slaves or criminals: they were imprisoned, tortured or killed. …” ]] - “…the vast majority of people dislike the adverse effects* of antipsychotics so much that 70% quit taking antipsychotics within the first year, often without any support from their psychiatrists. For instance, in one study of the drugs’ adverse effects, users reported ‘struggling to maintain daily functioning due to the side effects … weight gain, sleepiness, chronic diarrhea, confusion, dizziness, being cut off from feelings, loss of will-power’ and so forth. …” [Übersetzt in etwa: Die überwiegende Mehrheit der Menschen missbilligt die Nebenwirkungen* der Antipsychotika so sehr, dass 70 % innerhalb des ersten Jahres die Antipsychotika absetzen, oft ohne jegliche Unterstützung durch ihre Psychiater. So berichteten beispielsweise in einer Studie zu den Nebenwirkungen der Medikamente, dass die Konsumenten 'Schwierigkeiten hatten, den Alltag aufrechtzuerhalten, wegen der Nebenwirkungen ... Gewichtszunahme, Schläfrigkeit, chronischer Durchfall, Verwirrung, Schwindel, von Gefühlen abgeschnitten sein, Willensverlust und so weiter. …] [[ * Die sogenannten ‚Nebenwirkungen‘ sind keine Neben-, sondern auch Wirkungen … - Siehe dazu auch: Gedankensplitter – Neuroleptika, UAWs ]] - · “In my clinical experience, almost all patients really want to discontinue medication. That’s really a heartfelt desire for many of them.” Iris Sommer · [Nach meiner klinischen Erfahrung wollen fast alle Patienten wirklich die Medikation absetzen. Das ist tatsächlich ein aufrichtiger Wunsch für viele von ihnen.] Dazu bitte auch lesen: Commentary: Does First Year Treatment With an Antipsychotic Lead to Long-Term Harm? “…three notable efforts of this kind all found that a significant percentage of first-episode patients recovered without exposure to antipsychotics, and that it was this never-exposed group that had the best long-term outcomes. … So yes, it is heartening to see the drug-tapering studies. But what is also needed, and needed badly, are studies that assess long-term outcomes with selective-use models of care that avoid immediate use of antipsychotics. This Dutch study reinforces that need, for it does raise a question of whether a first year of treatment with antipsychotics, even at a moderate dose, induces iatrogenic changes in the brain that persist and take a long-term toll*.” [Übersetzt in etwa: …drei bemerkenswerte Studien dieser Art haben alle ergeben, dass ein signifikanter Prozentsatz der Patienten sich ohne Antipsychotika erholten, und dass diese nie exponierte Gruppe die besten langfristigen Ergebnisse erzielte. … Ja, es ist ermutigend, die Studien zur Ausschleichung von Medikamenten zu sehen. Was aber auch dringend benötigt wird, sind Studien, die langfristige Ergebnisse mit selektiven Behandlungsmodellen bewerten, die den sofortigen Einsatz von Antipsychotika vermeiden. Diese niederländische Studie unterstreicht diesen Bedarf, denn sie wirft die Frage auf, ob ein erstes Jahr Behandlung mit Antipsychotika, selbst in moderater Dosis, iatrogene Veränderungen im Gehirn hervorruft, die anhalten und sich langfristig negativ auswirken*.] [[ * …taking a long-term toll, ja, definitiv – und nicht nur durch die Antipsychotika, sondern vor allem auch durch die Diagnose (s.o.). ]] -- Siehe dazu auch den nachfolgenden Eintrag und: Eintrag 13.11.2025, 19.11.2025, 26.11.2025 Aktuelles – Estrogen/Cholesterin/Cortisol Ausserdem – Psychiatrie Blogbuchgedanken – Risperdal & Co. Und: Aktuelles – 1. Neue ‚Konzepte‘ wären hilfreich … ↓ Und dazu bitte auch lesen, zum Nachdenken: The relation between autism and psychosis: overlapping and differing features Ruas Resende M, Agostinho F, Nogueira R, et al. The relation between autism and psychosis: overlapping and differing features European Psychiatry : the Journal of the Association of European Psychiatrists. 2024 Aug;67(Suppl 1):S460-S461. PMCID: PMC11862380. https://europepmc.org/article/PMC/PMC11862380 “Conclusions: The diagnostic boundaries between ASD and SCZ are not always clear. Their overlapping characteristics and potential co-occurrence might pose important diagnostic challenges in clinical practice. …” |
| 18./20.11.2025 [[ Warum Ernährung oder vielmehr die Versorgung mit essenziellen Nährstoffen (Aminosäuren, Fette, Vitamine, Mineralstoffe, Spurenelemente …) wichtig ist - und nicht nur im Zusammenhang mit Autismus und ADHS. – Ich hoffe, dass es nicht zu unübersichtlich geraten ist, aber doch auch hier wieder deutlich wird, welch hochkomplexes ‚Gebilde‘ ein Mensch ist, und dass gerade im Hinblick auf diese Hochkomplexität insbesondere der Einsatz psychiatrischer ‚Medikamente‘ dringend hinterfragt werden sollte. ]] 1. The association between maternal prenatal folic acid* and multivitamin supplementation and autism spectrum disorders in offspring: An umbrella review Abate BB, Tusa BS, Sendekie AK, Temesgen D, Mekuria K, Alamaw AW, et al. (2025) The association between maternal prenatal folic acid and multivitamin supplementation and autism spectrum disorders in offspring: An umbrella review. PLoS One 20(11): e0334852. https://doi.org/10.1371/journal.pone.0334852 https://europepmc.org/article/MED/41252376 “Conclusion: Maternal prenatal folic acid and multivitamin supplementation are associated with a reduced risk of ASD in offspring. These findings have important public health implications, suggesting that prenatal supplementation could help mitigate the risk of ASD in children.” -- * Folsäure zählt generell – lt. Pschyrembel 2007 – zu den kritischen Nährstoffen fast aller Bevölkerungsgruppen; ein Mangel an Cobalamin (Vitamin B12) führt sekundär zu Folsäuremangel. – Folsäure gehört zu den wasserlöslichen Vitaminen; siehe dazu auch: Essen & Co. – Vitamine (‚Wasser-, Fettvitamine‘) -- Und siehe dazu auch: Fundstücke-09-2025, Eintrag 03.09.2025 Aktuelles – 1. Neue ‚Konzepte‘ wären hilfreich … Aktuelles - Autismus-Theorie Blogbuchgedanken – Aminosäuresequenzen Mineralstoffe Spurenelemente Etc. -- Und bitte lesen bei Wikipedia: Folsäure https://de.wikipedia.org/wiki/Fols%C3%A4ure [Biochemie: „Folsäure ist die Vorstufe des Coenzyms Tetrahydrofolsäure (THF). Die Reduktion von Folsäure zu Dihydrofolsäure ist Vitamin-C-abhängig. …“, Aufnahme und Speicherung, Physiologischer Bedarf, Folsäuremangel und Fehlbildungen, Risiken der Supplementation; Rechtliche Aspekte [u.a. Deutschland]: „Da zwei Drittel der Erwachsenen in Deutschland durchschnittlich weniger als 300 µg täglich aufnehmen, fordern einige Kinderärzte und einige Gesundheitspolitiker, dem Grundnahrungsmittel Mehl (wenn es nicht Vollkornmehl ist) Folsäure beizumengen. …“] In der englischen Wikipedia: Folate/Folic acid https://en.wikipedia.org/wiki/Folate [Health effects: Birth defects, Fertility, Heart disease, Stroke, Cancer, Neurological disorders (Dementia, Alzheimer’s disease), Clinical depression, Malaria; Absorption, metabolism and excretion; Drug interference, Dietary recommendations: Deficiency, Sources; Food fortification] · “Maternal folic acid supplementation during pregnancy is associated with a reduced risk of autism in children across Asian, European, and American populations. Cerebral folate deficiency, often caused by folate receptor alpha autoantibodies, is common in autism. Treatment with folinic acid appears to be safe, … A complex interaction occurs between folic acid, vitamin B12, and iron. A deficiency of folic acid or vitamin B12 may mask the deficiency of iron; so when taken as dietary supplements, the three need to be in balance. …” * * * 2. Tryptophan Metabolism in Neurodevelopment and Its Implications For Neurodevelopmental Disorders. Giuliano MG, Tognini P. Molecular Neurobiology, 20 Nov 2025, 63(1):97 https://doi.org/10.1007/s12035-025-05437-9 PMID: 41261305 PMCID: PMC12630162 https://europepmc.org/article/MED/41261305 „Abstract: The role of tryptophan metabolism has been recognized in a wide range of physiological and pathological processes but is still only partially understood. Growing evidence highlights the importance of maintaining tryptophan homeostasis throughout life, with its disruption now linked to various neuropsychiatric conditions spanning from early life to aging. …” ↓ Concluding Remarks and Open Questions [[ Eine der Fragen, die am Ende des Beitrags gestellt werden: ]] “Does an early-life imbalance in the KP [kynureine pathway] or gut microbiota-derived indole production contribute to the onset of ASD and ADHD, or exacerbate neurological symptoms in neurodevelopmental disorders more broadly?” -- ZUSAMMENHÄNGE - Infos bei Wikipedia: Tryptophan https://de.wikipedia.org/wiki/Tryptophan Daraus: „Der Spiegel dieser essentiellen L-Aminosäure in der Nährflüssigkeit des Gehirns ist nicht beliebig durch Verzehr entsprechend eiweißhaltiger Nahrung einstellbar, denn L-Tryptophan konkurriert mit fünf anderen Aminosäuren an der Blut-Hirn-Schranke um das Eindringen in die Nährflüssigkeit des Gehirns; nämlich mit den verzweigtkettigen (das sind L-Valin, L-Leucin und L-Isoleucin) und zwei aromatischen (L-Phenylalanin und L-Tyrosin) Aminosäuren.“ [Verwendung: Nahrungsergänzung/Ernährung, Verwendung als Antidepressivum] Tryptophan https://en.wikipedia.org/wiki/Tryptophan [Function; Dietary sources; Medical use: Depression, Insomnia; Side effects; Interactions] Kynurenin/Kynurenine https://de.wikipedia.org/wiki/Kynurenin Daraus: “Beim Menschen verläuft ein wichtiger Stoffwechselweg vom L-Tryptophan über L-Kynurenin und seine Metaboliten hin zur Nicotinsäure. …“ https://en.wikipedia.org/wiki/Kynurenine Daraus: „Kynurenine is a metabolite of the amino acid l-tryptophan used in the production of niacin. … Kynurenine is present in the lens and retina as one of multiple tryptophan derivatives produced in the eye, including 3-hydroxykynurenine, that together provide UV protection and aid in enhancing visual acuity. … Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine. Blood levels of kynurenine are reduced in people with bipolar disorder. Kynurenine production is increased in Alzheimer's disease and cardiovascular disease where its metabolites are associated with cognitive deficits and depressive symptoms. Kynurenine is also associated with tics. Myokines regulate it's metabolism. …” [Kynurenine pathway dysfunction] ! ↓ https://de.wikipedia.org/wiki/Myokine Daraus: “ Myokine sind hormonähnliche Botenstoffe, die von der Muskulatur der Säugetiere bei Bewegung und Kontraktion ausgeschüttet werden. …“ - https://en.wikipedia.org/wiki/Myokine [In brain functions related to neuroplasticity, memory, sleep and mood …] - Nicotinsäure/Niacin/Nicotinic acid https://de.wikipedia.org/wiki/Nicotins%C3%A4ure (Niacin, Vitamin B3) [Vorkommen und Eigenschaften; Biosynthese: (Chinolinsäure); Funktionen etc.] · „Nikotinsäure findet sich in allen lebenden Zellen und wird in der Leber gespeichert. Sie bildet einen wichtigen Baustein verschiedener Coenzyme (NAD, NADP) und ist in dieser Form von zentraler Bedeutung für den Stoffwechsel von Proteinen, Fetten und Kohlenhydraten. … Nikotinsäure ist von Bedeutung für die Regeneration von Haut, Muskeln, Nerven und DNS. …Nicotinsäure gilt als semi-essentiell, da es zwar aus einem Nebenweg des Tryptophan-Abbaus hergestellt werden kann, jedoch nicht bedarfsdeckend. …“ https://en.wikipedia.org/wiki/Nicotinic_acid [Biosynthesis: „In addition to absorbing niacin from diet, nicotinic acid can be synthesized from the essential amino acid tryptophan, a five-step process with the penultimate compound being quinolinic acid (see figure). For humans, the efficiency of conversion is estimated as requiring 60 mg of tryptophan to make 1 mg of niacin. Riboflavin, vitamin B6 and iron are required for the process. …”] ↓ https://de.wikipedia.org/wiki/Riboflavin#Mangelerscheinungen “… Häufig tritt eine Unterversorgung zusammen mit anderen B-Vitaminen auf. …Ohne gleichzeitige Zufuhr von Proteinen wird selbst bioverfügbares Riboflavin nicht mehr aufgenommen; daher geht ein Proteinmangel mit einem Vitamin-B2-Mangel einher. …Bei Neugeborenen kann ein Riboflavinmangel durch eine Phototherapie zur Behandlung einer Hyperbilirubinämie auftreten – Riboflavin ist lichtempfindlich und wird durch das Licht zerstört.“ https://en.wikipedia.org/wiki/Riboflavin#Deficiency “…Deficiency of riboflavin during pregnancy can result in fetal birth defects, including heart and limb deformities. …” [Causes] - https://de.wikipedia.org/wiki/Vitamin-B6-Mangel [Ursache; Klinische Erscheinung] https://de.wikipedia.org/wiki/Vitamin_B6#Mangelerscheinungen_(Hypovitaminose) [Anzeichen; U.a.: „Der Katabolismus von Vitamin B6 wird mittels valproin-säurehaltige Antiepileptika, Carbamazepin sowie Phenytoin erhöht, wodurch der Plasmaspiegel an PLP sinkt.“] [ ↓ PLP https://de.wikipedia.org/wiki/Pyridoxalphosphat https://en.wikipedia.org/wiki/Pyridoxal_phosphate ] ! https://en.wikipedia.org/wiki/Vitamin_B6#Deficiency “…In infants, a deficiency in vitamin B6 can lead to irritability, abnormally acute hearing, and convulsive seizures. Less severe cases … … …” [Causes] - https://de.wikipedia.org/wiki/Eisen#Medizinische_Bedeutung [Biologische Bedeutung; Medizinische Bedeutung: Eisenbedarf und Eisenmangel] https://en.wikipedia.org/wiki/Iron#Deficiency „ Iron deficiency is the most common nutritional deficiency in the world. … In the brain, iron plays a role in oxygen transport, myelin synthesis, mitochondrial respiration, and as a cofactor for neurotransmitter synthesis and metabolism. …” [(Parkinson), ADHD, Cancer] - https://de.wikipedia.org/wiki/Sphingosin https://en.wikipedia.org/wiki/Sphingosine - Indole https://en.wikipedia.org/wiki/Indole [General properties and occurrence; Tryptophan metabolism by human gut microbiota] - Cofaktor/Cofactor https://de.wikipedia.org/wiki/Cofaktor_(Biochemie) https://en.wikipedia.org/wiki/Cofactor_(biochemistry) -- Siehe dazu auch: Aktuelles – Chinolinsäure/Chinolinic acid Blogbuchgedanken – Aminosäuresequenzen Essen & Co. – Biosynthese von Sphingosin, ‘Wasser-Vitamine’ (Vitamin B2, B3, B6) Spurenelemente - Eisen Glossar – ATP, Antioxidative Enzyme, Biotransformation, Redoxsystem Zum Nachdenken – Eiweißabbau (-> Aufgaben von Dünn- und Dickdarm) Sekundäre Pflanzenstoffe -- Und bitte auch (noch einmal …) lesen, zum Nachdenken: Medical Organizations Turn Blind Eye to Harms of Maternal Antidepressant Use: A Conversation With Adam Urato and Joanna Moncrieff - [2016] New Study Finds Brain Changes in Newborns Exposed to Antidepressants „…The changes are associated with less-organized communication between the brain’s hemispheres and are comparable to the effects found in previous animal studies. The researchers call for more critical evaluations of the prescription of antidepressants during pregnancy and suggest that non-pharmacologic and therapeutic alternatives should be the preferred treatment. …” - Siehe dazu auch: Eintrag 28.11.2025 – 1. Fundstücke-10-2025, Eintrag 08.10.2025 |
| 18.11.2025 – 2. Are Clinical Training Models Fueling Mental Health Stigma? New Study Says Yes “…Stigma around mental health problems varies by diagnosis and is driven by fear and misunderstanding. …Research has found that mental health literacy campaigns do not reduce stigma, and may actually make it worse. One study found that mental health stigma was not linked to behaviors, but to labels given to people by mental health professionals. Research has also found that mental health professionals and service users often disagree on attributions of mental health problems, with service users preferring social explanations.” [Übersetzt in etwa: …Das Stigma gegenüber psychischen Problemen variiert je nach Diagnose und wird durch Angst und Missverständnisse verursacht. … Forschungsergebnisse zeigen, dass Kampagnen hierzu die Stigmata nicht verringern, sondern sogar verschlimmern können. Eine Studie ergab, dass diese Stigmata nicht mit Verhaltensweisen verbunden sind, sondern mit den von Fachkräften vergebenen ‚Etiketten‘. Forschungen haben außerdem gezeigt, dass oft Uneinigkeit besteht, was die Zuschreibung psychischer Probleme anbelangt …] Siehe dazu auch: Ausserdem – Psychiatrie Diskussionsseite – Zuschreibungen (…und wenn diese beschädigen) |
| 19.11.2025 – 1. Antidepressant Withdrawal: Finding an Astronomical Perspective – A Conversation with Safa Askeri https://www.madinamerica.com/2025/11/antidepressant-withdrawal-an-astronomical-perspective/ “… Askeri: I believe that mainstream psychiatry is probably the same all over the world. It has got differences, but I think it’s so misleading and terrible because of the many myths in psychiatry, like withdrawal doesn’t happen, and all those side effects can be blamed on your mental health condition. I think I witnessed this kind of iatrogenic injury in the hospital vividly. It was so terrible for me. After I found that I was being sabotaged by this medication, I also found that I was gaslit for many years because of the horrible side effects I got from these medications. If I reached out to psychiatrists, instead of addressing the withdrawal, they’d always blame my OCD and anxiety. … I think the mindset we had was totally wrong because we thought that this medication was going to fix the chemical imbalance. So it’s nothing to do with you, and you have to lie down and wait for a moment for this chemical to fix your brain. But it was not like that. It’s your job to fix your underlying problem by addressing the root cause. … I think we have to connect with each other, no matter how far apart we are. We have to eliminate all those wrong interpretations and just feel the humanity. Humanity, I think it’s the most important thing in the world. … Just give yourself time and continue the process because you’re going to see the light in the end of the tunnel and it’s such a great experience. Siem: Thank you so much, Safa. I think your light and your wisdom are just remarkable, and I think you’re going to help a lot of people. Thank you for taking the time.” -- Dazu bitte auch lesen: Easier to Refill Than Review: Antidepressant Prescribing in Primary Care https://www.madinamerica.com/2025/11/why-doctors-struggle-to-help-patients-come-off-antidepressants/ “…As a result of the numerous harms and negligible benefits, some researchers have said it’s time to stop recommending antidepressants for depression. Antidepressant withdrawal has been linked to severe, life-altering consequences. Slow tapering is likely the best way to limit withdrawal when stopping these drugs.” - We Need a Culture That Embraces Emotion Instead of Numbing It https://www.madinamerica.com/2025/11/we-need-a-culture-that-embraces-emotion-instead-of-numbing-it/ “…Our mental health system needs an overhaul. We need a culture that embraces emotion instead of hiding from it. Psychiatric medication should be used sparingly—as a last resort in tandem with additional treatment, with short-term use as the goal. …” -- Siehe dazu auch: Eintrag 26.11.2025 |
| 19.11.2025 – 2. Psychiatry: I no longer recognize the authorities of the mental monoculture From Mad in Denmark: “…The article has been out for about two weeks, but what Esben is referring to is a stagnant psychiatry that continues to offer the same treatment year after year. When we know that 82% of Danes will receive a psychiatric diagnosis during their lives, we, as Esben writes, need to start looking at other options for help than the usual. Likewise, when someone tries to offer something different, we need to draw attention to it so that they are not slaughtered because they dare to deviate from the usual treatment. …” [Übersetzt in etwa: …Der Artikel ist vor etwa zwei Wochen erschienen, aber worauf sich Esben bezieht, ist eine stagnierende Psychiatrie, die Jahr für Jahr dieselbe Behandlung anbietet. Wenn wir wissen, dass 82 % der Dänen im Laufe ihres Lebens eine psychiatrische Diagnose erhalten werden, müssen wir, wie Esben schreibt, anfangen, nach anderen Hilfsmöglichkeiten als der üblichen zu suchen. Ebenso müssen wir, wenn jemand versucht, in diesem Sinne etwas anderes anzubieten, darauf aufmerksam machen, damit er nicht ‚abgeschlachtet‘ wird, weil er es wagt, von der üblichen Behandlung abzuweichen. …] -- Dazu bitte auch lesen: Finding your tribe: Stories are the core of social psychiatry, not labels From Mad in Ireland. “Stories are the core of social psychiatry, not labels …” -- Siehe dazu auch: Eintrag 18.11.2025 – 1. Und zur Erinnerung: Buchempfehlung … Bruce D. Perry – Oprah Winfrey „What Happened To You – Conversations on Trauma, Resilience and Healing“ |
| 21.11.2025 Living Protracted https://www.madinamerica.com/2025/11/living-protracted/ “…There’s no denying the enormity of suffering this condition inflicts. I personally know individuals who’ve been housebound for over a decade, too sick to leave their homes, trapped in relentless symptoms: nerve pain, dystonia, crushing fatigue, sensitivities to sound, light, touch, even food. Neurological chaos. Mental anguish. The scope of it is so extreme, so prolonged, that many outside this experience struggle to believe it’s even real. This adds to the reasons why protracted withdrawal is often misattributed and misclassified. Its prevalence is also underestimated. … BIND*. This condition has taken so much from so many of us—years of our lives, our identities, our relationships, and the chance to simply feel safe in our own bodies and minds. And yet, despite the suffering, we have remained unseen, dismissed, or misunderstood by the very systems meant to help us. … It’s only when we raise our voices together—louder, stronger, more unified—that we become impossible to ignore. And in that noise, maybe, finally, change will come.” [* BIND = Benzodiazepine-induced neurological dysfunction] -- Infos bei Wikipedia: Ativan/Tavor = Lorazepam https://de.wikipedia.org/wiki/Lorazepam https://en.wikipedia.org/wiki/Lorazepam “…If stopped suddenly after long-term use, benzodiazepine withdrawal syndrome may occur. …” ↓ Benzodiazepine withdrawal syndrome https://en.wikipedia.org/wiki/Benzodiazepine_withdrawal_syndrome -- [[ Absetzprobleme - dazu habe ich zwei Fragen: Hatte ich nur einfach ‚Glück‘ (oder gehöre zu den Ausnahmen), weil ich Zolpidem völlig problemlos habe absetzen können, auch - oder vielleich auch nur dadurch -, weil ich stattdessen pflanzliche GABA in Form von Passiflora-Dragees zu mir genommen habe …? - Zolpidem gehört zwar nicht zu den Benzodiazepinen, hat aber eine vergleichbare Wirkung, und ich frage mich deshalb, ob größere Absetzprobleme (vielleicht auch) mit der jeweiligen Halbwertszeit zusammenhängen könnten, allerdings in diesem Falle anders, als ‚offiziell‘ dargestellt …? Offiziell heißt es, dass Medikamente mit längerer Halbwertszeit leichter abzusetzen wären – (und deshalb frage ich auch nur ganz ‚vorsichtig‘) … ]] ↓ Vergleich der Halbwertszeiten von Lorazepam (s.o.) und Zolpidem … Ambien/Zolpidem https://de.wikipedia.org/wiki/Zolpidem https://en.wikipedia.org/wiki/Zolpidem ↓ Halbwertszeit/Half-life* Die Halbwertszeit von Lorazepam bei Patienten mit normaler Leberfunktion beträgt zwischen 11 und 18 Stunden. / The biological half-life of lorazepam is 10–20 hours. - Zolpidem hat üblicherweise eine sehr kurze Halbwertszeit (2–3 Stunden) und keine pharmakologisch wirksamen Metaboliten. In vereinzelten Fällen werden jedoch auch bei weitem höhere Halbwertszeiten beobachtet (bis 10 Stunden). / It generally has a half-life of two to three hours. This, however, is increased in those with liver problems. ↓ https://de.wikipedia.org/wiki/Halbwertszeit „In der Pharmakokinetik ist Halbwertszeit die Zeit, in der die Hälfte des aufgenommenen Arzneimittels verstoffwechselt oder ausgeschieden ist.“ https://en.wikipedia.org/wiki/Biological_half-life „This is used to measure the removal of things such as metabolites, drugs, and signalling molecules from the body. …” -- [[ Und zum Nachdenken … Lt. englischer Wikipedia kann eine Psychose als ein Absetzsymptom von Benzodiazepinen auftreten … - Bedeutet dies denn nicht im Umkehrschluss, dass das, was Psychiater Schizophrenie oder Psychose nennen und ursächlich mit Dopamin in Verbindung bringen, tatsächlich anders behandelt werden sollte? (Und nach meiner Erfahrung: Ja, unbedingt!) – Siehe dazu auch: Peter C Gøtzsche - Is psychiatry a crime against humanity? 5 – Psychosis: „…Patients may want to be sedated when they have acute psychosis, but a Cochrane review showed that this can be better obtained with a benzodiazepine,525 which is what all the patients have wanted when I asked them during my lectures. But none of them got it. Patients are routinely treated with neuroleptics, even against their explicit will. …” (S. 76) Citation: Gøtzsche PC. Is psychiatry a crime against humanity? Copenhagen: Institute for Scientific Freedom; 2024 Buchdownload: Institute for Scientific Freedom Copenhagen www.scientificfreedom.dk -> Books: Download for free ]] -- Und siehe auch: Eintrag 13.11.2025 und 26.11.2025 Ausserdem – Psychiatrie Aktuelles – 1. Neue ‚Konzepte‘ wären hilfreich … Aktuelles - Katatonie („Angst-Stress-Trauma-Mechanismus“) Blogbuchgedanken – Schlafparalyse etc., Risperdal & Co., Zolpidem/GABA |
| 22.11.2025 Women Likely to Be Retraumatised by ECT: Disturbing Findings from a New Survey “…The mental health system often fails to respond in ways that support survivors to heal. Women deserve non-medicalised evidence-based options and choices, not retraumatisation. … We also know that women are at greater risk of harm because of their lower seizure thresholds, which may account for their reported worse outcomes. This is a fact recognized for over 30 years and recently reaffirmed by the American Psychiatric Association (2025). As a result, the same electrical dose is likely to cause more cognitive damage in women. …” [Übersetzt in etwa: …Das ‚mentale Gesundheitssystem‘ reagiert oft nicht auf eine Weise, die ‚Überlebende‘ bei ihrer Heilung unterstützt. Frauen verdienen nicht-medikalisierte, evidenzbasierte Optionen und Entscheidungen, und keine Retraumatisierung. …Wir wissen auch, dass bei Frauen aufgrund ihrer niedrigeren ‚Anfallsschwelle‘ ein höheres Risiko besteht, geschädigt zu werden, …Und dies ist eine Tatsache, die seit über 30 Jahren anerkannt und auch kürzlich von der American Psychiatric Association (2025) bestätigt wurde. Daher verursacht dieselbe elektrische Dosis wahrscheinlich mehr kognitive Schäden bei Frauen. …] - „Terror of experiencing it again. An urgent call for change. … We cannot allow a system that is meant to help and support people to instead continue to ignore their rights. …“ [Übersetzt in etwa: Angst, es noch einmal erleben zu müssen. Ein dringender Ruf nach Veränderung. …Wir dürfen nicht zulassen, dass ein System, das Menschen helfen und sie unterstützen soll, stattdessen weiterhin ihre Rechte ignoriert. …] -- Dazu bitte auch lesen: Electroconvulsive therapy (ECT): It’s Not Just the Memory Loss https://www.madinamerica.com/2025/11/electroconvulsive-therapy-ect-its-not-just-the-memory-loss/ “A new study shows ECT can cause disastrous health and cognitive problems, and chronic impairments across many day-to-day activities. …] [Übersetzt in etwa: Eine neue Studie zeigt, dass EKT katastrophale Gesundheits- und kognitive Probleme sowie chronische Beeinträchtigungen bei vielen täglichen Aktivitäten verursachen kann. …] -- Zu EKT/ECT siehe auch: Fundstücke-09-2025, Eintrag 23.09.2025 Fundstücke-06-2025, Eintrag 17.06.2025 Und bei Wikipedia: Elektrokrampftherapie - Kritik … https://de.wikipedia.org/wiki/Elektrokonvulsionstherapie Daraus: “Metastudien aus dem Jahr 2010 und 2017 attestieren der Elektro-konvulsionstherapie in Abwägung der Vor- und Nachteile keinen positiven Nutzen.“ In der englischen Wikipedia: |
| 26.11.2025 The Damage Doesn’t End When the Drugs Do: Diana Rose on Psychiatry’s Long Shadow “Ayurdhi Dhar interviews survivor-researcher Diana Rose on her long-term adverse experiences from psychiatric drugs, survivor knowledge, and the humiliations built into the system. … She is someone with lived experience of madness, a service-user, and a survivor. In a previous interview, we discussed her pathbreaking work on user-led research, which values the knowledge of people with lived experience. Since that interview, Rose has been diagnosed with drug-induced Parkinsonism caused by the scores of neuroleptics she was put on over the years. In this rather intimate interview, we will discuss her life, her struggles, and how other patients had better knowledge about treatment adverse effects than most practitioners. We will also cover how, contrary to popular belief, psychiatric drugs have continuing adverse effects even years after stopping them. … You really never thought about psychiatry as a schooling in humiliation? Of course, it is! It makes you think about all the things that are wrong with you as a normal human being. … I don’t want to come across as 100% anti-antipsychotic*. They can be OK in a very short term, like a week or two, so you can start to talk about what’s happening to you. But not for 20, 40, 50 years. …” -- Verlinkung im Text: Antipsychotics Do Not Provide a Clinically Meaningful Benefit Over the Short-Term: A Review of the Evidence “Seventy years of RCTs have failed to provide evidence that antipsychotics provide a clinically meaningful benefit for treating acute psychotic episodes. …” -> Siehe dazu auch: Fundstücke-06-2025, Eintrag 21.06.2025 -- Infos bei Wikipedia: Parkinsonismus/Parkinson-Syndrom https://de.wikipedia.org/wiki/Parkinson-Krankheit https://en.wikipedia.org/wiki/Parkinson%27s_disease -- Siehe dazu auch: Aktuelles – Dopamin-Hypothesen, Parkinsonismus Blogbuchgedanken – LBD/Parkinson, Insulinschocktherapie, Risperdal & Co. Zum Nachdenken – Hypoglykämie Gedankensplitter – Neuroleptika, UAWs |
| 28.11.2025 – 1. International Seminar Debates Demedicalization and the Future of Mental Health in Brazil ↓ Aus der Übersetzung: “Creator of Mad in America gives opening lecture …Whitaker pointed out that although psychiatric drugs, approved by the U.S. Food and Drug Administration, appear to show short-term statistical benefit when compared to placebo, reducing symptoms is not always clinically significant. Concern extends to assessments of long-term use in which, according to the studies presented, patients not medicated for depression or psychotic disorders may have better results over time than those medicated. … - Antidepressants in pregnancy In the afternoon, the table “Evidence in the use of antidepressants in pregnancy” brought together the biologist and professor of psychopharmacology Marcos Ferraz and the obstetrician Adam Urato. … - The table “Demedicalizing practices in mental health” gathered personal and professional reports. … - Culture and resistance close the event “…With dense debates and plural experiences, the 9th International Seminar The Epidemic of Psychiatric Drugs reaffirmed the importance of thinking about care in freedom, based on critical evidence, listening and social responsibility. Fiocruz is once again consolidated as a space of resistance and production of new paradigms in mental health. …” ↓ |
| 28.11.2025 – 2. Can Finding Meaning Heal? New Review Maps the Evidence for Logotherapy https://www.madinamerica.com/2025/11/meaning-centered-logotherapy-shows-promise-review-finds/ “…Taken together, this review adds to the growing conversation about what mental health care could look like when it moves beyond symptom suppression and toward helping people cultivate meaning, purpose, and relational connection—especially during times of collective uncertainty.” -- Infos bei Wikipedia: Logotherapie / Logotherapy – Viktor Frankl, in memoriam … https://de.wikipedia.org/wiki/Logotherapie_und_Existenzanalyse „…Viktor Frankls originäres Konzept der Logotherapie und Existenzanalyse umfasst eine grundlegende Theorie über die Möglichkeiten und Bedingungen für ein menschenwürdiges Dasein (Logotheorie). …“ - https://en.wikipedia.org/wiki/Logotherapy [Basic principles; Logotherapeutic views and treatment; Recent developments: “…These recent developments introduce Viktor Frankl's logotherapy to a new generation and extend its impact to new areas of research.”] -- Siehe dazu auch: Eintrag 13.11.2025 |
|
|
| #MIA-History … [2017] Schizophrenia’s Tangled Roots https://www.madinamerica.com/2017/07/schizophrenias-tangled-roots/ From Sapiens: “…Yet modern psychologists who work directly with patients who suffer from schizophrenia and other forms of psychosis are sometimes able to identify environmental factors—ranging from childhood abuse or adversity to stressful events in adolescence or early adulthood—that can trigger a psychotic breakdown.” [Übersetzt in etwa: …Doch moderne Psychologen, die direkt mit Patienten arbeiten, die an Schizophrenie und anderen Formen von Psychosen leiden, können manchmal Umweltfaktoren identifizieren – von Missbrauch oder Widrigkeiten in der Kindheit bis hin zu stressigen Ereignissen in der Jugend oder frühen Erwachsenenzeit –, die einen psychotischen Zusammenbruch auslösen können.] -- [[ Also auch hier: Nicht fragen, was ‚falsch‘ ist an einer Person, sondern fragen: Was ist passiert? – Siehe dazu auch: Eintrag 19.11.2025 – 2. ]] -- Und siehe dazu auch: Aktuelles – 1. Neue ‘Konzepte’ wären hilfreich … Blogbuchgedanken – Schizophrenie, ‚Spaltungsirresein‘ Diskussionsseite – Begriffsentstehung, Zuschreibungen |
|
|
| #MeTooInMentalHealth … A Hospital Surgeon Falls Victim to Psychiatry https://www.madinamerica.com/2025/11/a-hospital-surgeon-falls-victim-to-psychiatry/ “…It was all a terrible dream. All due to unnecessary drugs. … Now off all medications for 18 months I have regained my cognitive capacity again, except for the severe memory loss due to the multiple ECTs. I also still have the mobility problems …”
“I was forcibly medicated for a psychosis I never had” https://www.madinamerica.com/2025/11/i-was-forcibly-medicated-for-a-psychosis-i-never-had/ From Mad in Sweden. – Aus der Übersetzung: “…An infection – not a psychosis …The consequences have been devastating. … Nobody has listened. …My biggest mistake was seeking psychiatric help. A system that fails I feel that psychiatry is rarely on the side of patients. They think that a pill will solve the problem. … Many people end up taking their own lives on antipsychotic medications. When the brain is blocked from dopamine – a neurotransmitter that is crucial for feeling joy – the will to live disappears. I felt like a zombie, spent most of my time in bed and only became more anxious. …”
The List: Flashbacks and Failures https://www.madinamerica.com/2025/11/the-list-flashbacks-and-failures/ “…I wonder if the version of me from 2017 just wants to be heard, understood, validated and integrated. Sometimes she knocks quietly, other times she rages and seems to be trying to burst out of me. One thing for sure though is that she is here and, despite it all, I am very much here too.”
Where the Bullet Stayed https://www.madinamerica.com/2025/11/where-the-bullet-stayed/ “…There’s a story we like to tell: that time heals all wounds. It doesn’t. Time just teaches us to carry them differently. … We don’t move on from our wounds. We move with them. And maybe that’s enough. Maybe the myth isn’t that healing exists. Maybe the myth is that it ever ends.”
Psychiatrists Do Not Apologize - Siehe auch Eintrag 13.11.2025 https://www.madinamerica.com/2025/11/psychiatrists-do-not-apologize/ “…In other words, psychiatrists destroyed our lives. … The failure to apologize brings untold pain to us victims. …” |
| R. I. P. … Remembering Steven Morgan https://www.madinamerica.com/2025/11/remembering-steven-morgan/ “…People who, in many cases, would have been lost had they followed the path that a diagnosis had once laid out for them. There is no better example than Steven Morgan; a paragon of healthy living, even as he contended with illnesses that made daily living a challenge and took his life this week. …” Kermit Cole |
Danke fürs ‘Zuhören’.
♥